The formulas of Animalkine are produced from a unique combination of systems and paradigms. Blending the experience and skill of senior herbalists, creating formulas from both an Eastern and Western herbal medicine paradigm and allowing for perfectly balanced formulas from energetic and research based approaches.
The state of the art: Doctors now compliment traditional medicine with alternative disciplines such as Chinese herbs. Director of MAYO CLINIC integrative medicine program reveals marked improvement of more then 18,000 patients. Mayo isn't the only visionary hospital in the U.S. with a thriving integrative-medicine program. Merits of integrative medicine with people is real and growing and this rings true with animals. It is time our animals receive the same benefits. Think of where any of us would be without the animals we share our planet with...
There is a long history of using herbs for farm, wild and domestic animals for thousands of years. In many remote, rural areas of the world herbal medicine is the primary medicine for both animals and humans.
According to the WHO (World Health Organization) “The use of TM (Traditional Medicine) has changed dramatically over the past thirty years. Due to its affordability, availability and accessibility, TM has played an important role in meeting the demands of primary health care in many developing countries, particularly in Africa and Asia. Since the 1990s, the use of TM has surged. It not only maintains its function in primary health care in developing countries (70-80% of the population in India and Ethiopia still depend on TM and practitioners for primary health care), but its use has expanded widely in many developed countries where it is referred to as Complementary or Alternative Medicine (CAM). For instance, 70% of the population in Canada and 80% in Germany have used TM as CAM treatment.” http://www.who.int/medicines/areas/traditional/en/
Some of the research that has been done with the herbs is listed below to give an idea of some of the more science/biological thoughts behind the ingredients; but it is important to remember that when the herbs are combined together in a unique, energetically balanced formula, based on thousands of years of traditional uses, that something positive, beyond the purely medical/biological/researched begins to transpire.
The research below is collected from human and animal, in vitro and in vivo. I encourage everyone to research each herb for its uses, safety and efficacy. Although we put these formulas together to address the most common issues that arise with animals, each animal is a unique case. Be sure to consult an animal specialist who is well trained in herbal veterinary medicine. Any animal that is taking prescription drugs or undergoing surgery should be sure to inform their veterinarian to prevent any negative combinations.
Countries with a strong commitment to traditional medicines and a vested interest in providing high quality low cost medical care find the need to do the research. Because of this we find our primary research form England, France, Israel, China, Taiwan, Russia, Japan, India, Cuba and many other countries.
The following herbs are just a sampling of the over 50 carefully selected herbs in the extensive line of Animalkine formulas. Each of the herbs has a vital role in the formula and has just as an extensive list of research to support is use.
Olive Leaf - Olea europaea
Olive Leaf demonstrates some antibiotic and antiviral properties. It appears to effect viruses in infected cells from replicating. Olive leaf has natural phytochemicals, including oleuropein and associated antioxidants. Many of these natural chemicals have been the subject of research, especially the oleuropein. The various phytochemicals have shown to significant effect on various strains of bacteria, spirochetes, rickettsiae, chlamydiae, fungi, yeasts, molds, viruses, protozoa, helminths, and other parasites.
Although no research appears to have been done to date of olive leaf extract as an FIV therapy, research as an HIV therapy has been so promising that a number of researchers have pointed to the possibility of creating new HIV drugs based on synthetic derivatives. One study in 1998 suggested that olive leaf worked as a reverse transcriptase inhibitor. However, more recent studies have identify oleuropein, the chief active constituent of OLE, and its metabolite hydroxytyrosol, as HIV inhibitors at both the fusion and integration stages, the former by binding the viral envelope protein responsible for fusion and the latter by inhibition of the viral enzyme integrase at three separate points
. FEBS Lett. 2007 Jun 12;581(14):2737-42. Epub 2007 May 21. Computational study of bindings of olive leaf extract (OLE) to HIV-1 fusion protein gp41. Bao J1, Zhang DW, Zhang JZ, Huang PL, Huang PL, Lee-Huang S
Olive leaf extract-was first mentioned in the bible and recent research confirms the effectiveness against a wide variety of microbial infections. A U.S Department of Agriculture study published in the Journal of Food Science confirms that olive leaf extract is effective in fighting food-borne pathogens like salmonella and E.coli, labeling it a broad spectrum antimicrobial. New York University School of Medicine research published in Biochemical and Biophysical Research Communications showed that olive leaf extract reversed many HIV related changes in the immune system.
Huang Qi - Astragalus membranaceus
Huang Qi (Astragalus m.) is well known in traditional Chinese medicine. It has demonstrated its safe and effective ability to activate and maintain a healthy immune system. It seems to assist the body in unique ways to address everything from digestion, energy levels and combat yeast, bacteria and viruses.
The effect of Astragalus polysaccharide on the Epstein-Barr virus lytic cycle. Acta Virol. 2014;58(1):76-80. Guo Q, Sun X, Zhang Z, Zhang L, Yao G, Li F, Yang X, Song L, Jiang G. Effects of Astragalus polysaccharide on immune responses of porcine PBMC stimulated with PRRSV or CSFV. PLoS One. 2012;7(1):e29320. doi: 10.1371/journal.pone.0029320. Epub 2012 Jan 9. Zhuge ZY1, Zhu YH, Liu PQ, Yan XD, Yue Y, Weng XG, Zhang R, Wang JF.
Chuan Xin Lian - Andrographis paniculata
Known as Chuan Xin Lian in Traditional Chinese Medicine, Andrographis has demonstrated such a wide range of activity that it is considered to have a positive effect on most inflammatory and viral disorders. Chinese and Ayurvedic medicine specifically use it for swollen glands and acute fevers among other issues.
Eur J Med Chem. 2012 Oct;56:368-74. doi: 10.1016/j.ejmech.2012.07.030. Epub 2012 Jul 24. Anti-HIV activity of semisynthetic derivatives of andrographolide and computational study of HIV-1 gp120 protein binding. Uttekar MM1, Das T, Pawar RS, Bhandari B, Menon V, Nutan, Gupta SK, Bhat SV. Int Immunopharmacol. 2013 Aug;16(4):451-6. doi: 10.1016/j.intimp.2013.05.002. Epub 2013 May 23. Preventive effects of andrographolide on the development of diabetes in autoimmune diabetic NOD mice by inducing immune tolerance. Zhang C1, Gui L, Xu Y, Wu T, Liu D. Clin Rheumatol. 2009 Aug;28(8):931-46. doi: 10.1007/s10067-009-1180-5. Epub 2009 Apr 29. Efficacy of an Andrographis paniculata composition for the relief of rheumatoid arthritis symptoms: a prospective randomized placebo-controlled trial. Burgos RA1, Hancke JL, Bertoglio JC, Aguirre V, Arriagada S, Calvo M, Cáceres DD
Cat's Claw Uncaria tormentosa
Cat’s Claw can help the body regulate T-Cell formation to a normal level which is important in AIDs/FIV. It is known to have caused remission of some sarcomas. Cats Claw has been used by the natives of Peru for hundreds of years for a range of acute and chronic inflammatory disorders. It has also been studied for its ability to support healthy cells. (Rizzi, R., Re, F., Bianchi, A., De, Feo, V, De Simone, F., Bianchi, L., and Stivala, L. A. “Mutagenic and antimutagenic activities of Uncaria tomentosa and its extracts.” J.Ethnopharmacol. 1993;38(1):63-77) Antigenotoxicity, cytotoxicity, and apoptosis induction by apigenin, bisabolol, and protocatechuic acid. Anter J1, Romero-Jiménez M, Fernández-Bedmar Z, Villatoro-Pulido M, Analla M, Alonso-Moraga A, Muñoz-Serrano A.
Clove - Syzygium aromaticum
Clove is an often forgotten herb that is used in many tradition cultures. It can be used for everything from viral issues to improving digestion. It also has a wide range of phytochemicals that have been researched for bioactivity. One of the phytochemicals in clove, Eugenol, was tested on its effect on Autophagy. Autophagy has been seen as vital in programmed cell death and the body’s ability to respond to different health issues, both acute and chronic. Autophagy assists in response to diseases such as cancer, cardiovascular disease and virus infection, including human immunodeficiency virus (HIV), hepatitis C virus (HCV), influenza A virus (IAV) and coxsackievirus B3/B4 (CVB3/B4). The research looked at 86 examples of traditional Chinese medicines and found that clove had the best activity. Eugenol also ameliorated the oxidative stress and inhibited the expressions of autophagic genes.
Drug screening for autophagy inhibitors based on the dissociation of Beclin1-Bcl2 complex using BiFC technique and mechanism of eugenol on anti-influenza A virus activity. Dai JP1, Zhao XF, Zeng J, Wan QY, Yang JC, Li WZ, Chen XX, Wang GF, Li KS. J Med Microbiol. 2014 Jan;63(Pt 1):74-85. doi: 10.1099/jmm.0.064709-0. Epub 2013 Oct 25. Apoptosis-like death in Leishmania donovani promastigotes induced by eugenol-rich oil of Syzygium aromaticum. Islamuddin M1, Sahal D, Afrin F. Oncol Res. 2014;21(5):247-59. doi: 10.3727/096504014X13946388748910. Clove extract inhibits tumor growth and promotes cell cycle arrest and apoptosis. Liu H1, Schmitz JC, Wei J, Cao S, Beumer JH, Strychor S, Cheng L, Liu M, Wang C, Wu N, Zhao X, Zhang Y, Liao J,
St. John's WortHypericum perforatum
St. Johns Wort is one of those herbs that we continue to learn more about on a regular basis. Because it is traditionally known for its positive effects on emotions it is often used for depression. Some practitioners believe that emotional distress has an effect on many issues from premature aging, cancer, obesity and digestive issues. We find that St. Johns Wort works synergistically in many of our formulas.
Nutr Res Pract. 2014 Jun;8(3):292-6. doi: 10.4162/nrp.2014.8.3.292. Epub 2014 May 15. Effect of St. John's Wort (Hypericum perforatum) on obesity, lipid metabolism and uterine epithelial proliferation in ovariectomized rats. You MK1, Rhuy J1, Jeong KS2, Bang MA3, Kim MS4, Kim HA1. Int J Psychiatry Clin Pract. 2013 Nov;17 Suppl 1:1-7. doi: 10.3109/13651501.2013.813554. Hypericum extract WS ® 5570 for depression--an overview. Gastpar M. Biomed Chromatogr. 2014 Mar 17. doi: 10.1002/bmc.3169. [Epub ahead of print] Quality and antitumour activity evaluation of extract of Hypericum ascyron. Li XM1, Luo XG, Ma N, Li K, Li W, Ma DY, Zhang TC.
Huang QinScutellaria baicalensis A commonly used Traditional Chinese Medicine herb containing unique phytochemicals such as Baicalein and Berberine, is used for infections in the upper part of the body. The review below sums up its many researched and traditional uses. “Effective against staphylococci, cholera, dysentery, pneumococci and influenza virus….Baicalein, possesses a multitude of pharmacological activities. Baicalin is a potent anti-inflammatory and anti-tumor agent and associated with the prevention and treatment of cardiovascular diseases. Baicalein is a potent free radical scavenger and xanthine oxidase inhibitor, thus improving endothelial function and conferring cardiovascular protective actions against oxidative stress-induced cell injury. Baicalein lowers blood pressure in renin-dependent hypertension and the in vivo hypotensive effect may be partly attributed to its inhibition of lipoxygenase, resulting in reduced biosynthesis and release of arachidonic acid-derived vasoconstrictor products. The anti-thrombotic, anti-proliferative and anti-mitogenic effects of the roots of S. baicalensis and baicalein are also reported. Baicalein inhibits thrombin-induced production of plasminogen activator inhibitor-1, and interleukin-1beta- and tumor necrosis factor-alpha-induced adhesion molecule expression. Curr Drug Targets Cardiovasc Haematol Disord. 2005 Apr;5(2):177-84. Biological properties of baicalein in cardiovascular system. Huang Y1, Tsang SY, Yao X, Chen ZY.
Wormseed/Epazote - Dysphania ambrosioides Epazote is a common food ingredient in Central and South America. It is used in bean dishes to reduce flatulence. Wormseed is also still commonly added to livestock feed to use for worms of many types. Epazote can also be helpful with a variety of inflammatory conditions. J Ethnopharmacol. 2013 Jan 9;145(1):127-38. doi: 10.1016/j.jep.2012.10.040. Epub 2012 Nov 1.From popular use to pharmacological validation: a study of the anti-inflammatory, anti-nociceptive and healing effects of Chenopodium ambrosioides extract. TrivellatoGrassi L1, Malheiros A, Meyre-Silva C, Buss Zda S, Monguilhott ED, Fröde TS, da Silva KA, Exp Parasitol. 2010 Oct;126(2):191-7. doi: 10.1016/j.exppara.2010.04.023. Epub 2010 May Toxocara canis: potential activity of natural products against second-stage larvae in vitro and in vivo. Reis M1, Trinca A, Ferreira MJ, Monsalve-Puello AR, Grácio MA.
Black walnutJuglans nigra
Black Walnut is a well-known herb used for intestinal parasites. Despite the long tradition of using this herb, there have been very few clinical trials of its effectiveness. But, traditional use, in combination with other herbs, has shown good success against parasites. Vet Parasitol. 2007 Sep 30;148(3-4):325-40. Epub 2007 Jul 12. Ethnoveterinary medicines used to treat endoparasites and stomach problems in pigs and pets in British Columbia, Canada. Lans C1, Turner N, Khan T, Brauer G.
Aloe has long been used to assist with constipation, parasites and gastrointestinal inflammation in general. It is used internally and externally and is now so effective for skin issues that we can new find the fresh stalks sold in grocery stores in the produce section of mainstream food stores. Parasitol Res. 2012 Jan;110(1):103-8. doi: 10.1007/s00436-011-2455-8. Epub 2011 May 24. In vivo validation of Aloe ferox (Mill). Elephantorrhiza elephantina Bruch. Skeels. and Leonotis leonurus (L) R. BR as potential anthelminthics and antiprotozoals against mixed infections of gastrointestinal nematodes in goats.Maphosa V1, Masika PJ.
Sweet Annie/Qing Hao – Artimesia annua
Research is exploding on this common weed. An extract of Sweet Annie is used by the WHO worldwide for effective control of malaria. New research demonstrates its effectiveness for certain types of cancers. All of the Artimesias (Wormwoods) are well known anti-parasitics and liver/gall bladder stimulators. Vet Parasitol. 2011 Jan 10;175(1-2):103-8. doi: 10.1016/j.vetpar.2010.09.011. Epub 2010 Sep 16. Effects of artemisinin and Artemisia extracts on Haemonchus contortus in gerbils (Meriones unguiculatus). Squires JM1, Ferreira JF, Lindsay DS, Zajac AM. Nat Prod Bioprospect. 2014;4:113-118. Epub 2014 Apr 12. Treatment of Iron-Loaded Veterinary Sarcoma by Artemisia annua. Breuer E1, Efferth T2. Pharmacol Ther. 2014 Apr;142(1):126-39. doi: 10.1016/j.pharmthera.2013.12.001. Epub 2013 Dec 6. Artemisinins: pharmacological actions beyond anti-malarial. Ho WE1, Peh HY2,
This pleasant smelling arctic plant named after roses is unrelated. It has long been known as a relaxing adaptogenic herb that is growing in use. It helps the user to adapt to stress, increases endurance, improves sleep and reduces anxiety. Phytomedicine. 2010 Jun;17(7):481-93. doi: 10.1016/j.phymed.2010.02.002. Epub 2010 Apr 7. Rosenroot (Rhodiola rosea): traditional use, chemical composition, pharmacology and clinical efficacy. Panossian A1, Wikman G, Sarris J. J Altern Complement Med. 2008 Mar;14(2):175-80. doi: 10.1089/acm.2007.7117. A pilot study of Rhodiola rosea (Rhodax) for generalized anxiety disorder (GAD). Bystritsky A1, Kerwin L, Feusner JD. Nord J Psychiatry. 2007;61(5):343-8 Clinical trial of Rhodiola rosea L. extract SHR-5 in the treatment of mild to moderate depression. Darbinyan V1, Aslanyan G, Amroyan E, Gabrielyan E, Malmström C, Panossian A.
Mad Dog Skullcap - Scutellaria lateriflora
This commonly used American herb is used to strongly reduce anxiety and insomnia. It can be eaten, smoked or used as tea. It also has been used traditionally as an anti-seizure medication. CNS Drugs. 2013 Apr;27(4):301-19. doi: 10.1007/s40263-013-0059-9. Plant-based medicines for anxiety disorders, part 2: a review of clinical studies with supporting preclinical evidence. Sarris J1, McIntyre E, Camfield DA.
Linden leaf – Tilia sp
Linden trees are an often forgotten herb that grows in Europe and the Americas. Traditionally it is used as an anti-anxiety, blood pressure reducer and sleep enhancer. Very little formal research has been done on this simple plant despite the traditional cross-cultural similarities of its use and long safety history. CNS Drugs. 2013 Mar;27(3):207-19. doi: 10.1007/s40263-013-0044-3. Plant-based medicines for anxiety disorders, Part 1: a review of preclinical studies. Sarris J1, McIntyre E,
Marigold flower - Calendula officinalis
This beautiful annual flower is a gentle and safe herb traditionally used both topically and internally for a variety of skin issues. Once again we see the traditional use of this herb cross culturally for the identical use. It is effective for acute and chronic conditions. J Indian Soc Periodontol. 2013 Nov;17(6):741-7. doi: 10.4103/0972-124X.124491. Evaluation of Calendula officinalis as an anti-plaque and anti-gingivitis agent. Khairnar MS, Pawar B, Marawar PP, Mani A. Evid Based Complement Alternat Med. 2012;2012:375671. doi: 10.1155/2012/375671. Epub 2012 Jan 24.\ Wound Healing and Anti-Inflammatory Effect in Animal Models of Calendula officinalis L. Growing in Brazil. Parente LM1, Lino Júnior Rde S, Tresvenzol J Basic Clin Physiol Pharmacol. 2009;20(1):73-9. Wound healing activity of flower extract of Calendula officinalis. Preethi KC1, Kuttan R.
Plantain – Plantago spp
Almost every species of this plant is used medicinally around the world. It is perhaps best known for its positive effect on skin and wound healing. It is used internally for a variety of issues of the digestive tract and has shown great promise on a variety of inflammatory digestive disorders. J Ethnopharmacol. 2000 Jul;71(1-2):1-21. The traditional uses, chemical constituents and biological activities of Plantago major L. A review. Samuelsen AB. Phytother Res. 2000 Dec;14(8):617-22. Immunoenhancing properties of Plantago major leaf extract. Gomez-Flores R1, Calderon CL, Scheibel LW, Tamez-Guerra P, Rodriguez-Padilla C, Tamez-Guerra R, Weber RJ.
Han Lian Cao - Eclipta prostrate
Eclipta is used by many countries and is being researched for its effects on parasites, cancer, snake bites, hair growth, anti-inflammatory and liver/kidney function. In china it is used in combinations to assist in liver function primarily. Phytother Res. 2011 Feb 10. doi: 10.1002/ptr.3383. [Epub ahead of print] Antiinflammatory Constituents from Eclipta prostrata using RAW264.7 Macrophage Cells. Tewtrakul S1, Subhadhirasakul S, Tansakul P, Cheenpracha S, Karalai C. Nutr Res. 2010 Aug;30(8):579-84. doi: 10.1016/j.nutres.2010.08.001. The butanol fraction of Eclipta prostrata (Linn) increases the formation of brain acetylcholine and decreases oxidative stress in the brain and serum of cesarean-derived rats. Kim DI1, Lee SH, Hong JH, Lillehoj HS, Park HJ, Rhie SG, Lee GS. In Vivo. 2008 May-Jun;22(3):363-8. Juice of eclipta prostrata inhibits cell migration in vitro and exhibits anti-angiogenic activity in vivo. Lirdprapamongkol K1, Kramb JP, Chokchaichamnankit D, Srisomsap C Surarit R Sila Ansa R
Peppermint - Mentha piperita Lemon Balm-Melissa officinalis
Peppermint and Lemon Balm are combined together to ensure that the symptoms are addressed from both an emotional and physical perspective. Both plants are in the mint family and are well researched for IBS, bloating, microbial overgrowth. Lemon Balm also uniquely is known to reduce stress without causing sedation.
Gentian - Gentiana lutea
Gentian is considered one of the premier digestive bitters with a long history of stimulating appetite and improving gastric secretions to improve nutrient absorption. Gentian is also classified energetically as a cold herb that counters the slightly energetic warming properties of St. Johns Wort. The addition of this herb enhances the effectiveness of the other herbs in the formula by enhancing digestion/absorption.
Acacia – Acacia sengal
Acacia, a researched and traditional medicine herb from the middle east/north Africa. It is a potent anti-inflammatory and aids the healthy promotion of beneficial gut flora. Acacia is also a gentle source of fiber to help with normalizing bowel elimination
Chamomile - Matricaria chamomilla
Chamomile is a classical carminative used to aid in bloating, gas, distention, nervous diarrhea and other digestive related symptoms. It contains gentle antimicrobial properties and combines very well energetically with Lemon Balm and Peppermint
Marshmallow- Althaea officinalis
Marshmallow is a cooling demulcent. Though classically used for dry cough issues, traditional medicine recognizes the connection between the lung and large intestine. Marshmallow has been researched in its ability to assist in the regeneration of epithelial cells and normalizing the mucosal linings in the body.
Licorice - Glycyrrhiza glabra
Licorice is a multidimensional herb. Historically known as a cooling herb that harmonizes any formula creating a synergistic action throughout the body. Research shows the ability of licorice to reduce H. pylori levels in the stomach and significantly reduce ulcers. Licorice also is a well-known cooling demulcent that works well with Marshmallow. There is also significant research of licorice’s anti-inflammatory and steroidal-like action that enhances its benefits to the digestive system and body as a whole.